Table 1. Pathway enrichment analysis of metformin-suppressed metabolites from MKR mice.
| KEGG pathway_name | Pathway ID | Overlapping Metabolites | All Metabolites | Pmetabolites | Qmetabolites |
|---|---|---|---|---|---|
| Alanine, aspartate and glutamate metabolism | KO00250 | C00158;C01042;C00022;C00025;C00026;C00232;C00042;C00122 | 28 | 7.67E-09 | 1.39E-06 |
| Citrate cycle (TCA cycle) | KO00020 | C00158;C00149;C00417;C00026;C00042;C00022;C00122 | 20 | 1.44E-08 | 2.28E-06 |
| Glyoxylate and dicarboxylate metabolism | KO00630 | C00158;C00160;C00149;C00417;C00025;C00026;C00042;C00898;C00022 | 58 | 2.60E-07 | 2.40E-05 |
| Butanoate metabolism | KO00650 | C01089;C00022;C00025;C00026;C00232;C00042;C00122 | 41 | 3.18E-06 | 0.000193 |
| Histidine metabolism | KO00630 | C00860;C02835;C00025;C00026;C00785;C05570;C00439 | 45 | 6.11E-06 | 0.000333 |
| Vitamin B6 metabolism | KO00750 | C00022;C00118;C00026;C00279;C00847;C00232 | 32 | 9.62E-06 | 0.000457 |
| Pentose phosphate pathway | KO00030 | C00117;C00022;C00118;C00279;C00221;C00121 | 35 | 1.66E-05 | 0.000735 |
| Glutathione metabolism | KO00480 | C01672;C00072;C00750;C00025;C00051;C00134 | 38 | 2.71E-05 | 0.00111 |
| Cysteine and methionine metabolism | KO00270 | C00022;C00094;C00979;C00059;C00491;C03145;C00051 | 57 | 3.05E-05 | 0.00124 |
| Arginine and proline metabolism | KO00330 | C00750;C00025;C00437;C04281;C00581;C00022;C00134;C00122 | 90 | 8.63E-05 | 0.00273 |
| Ascorbate and aldarate metabolism | KO00053 | C00072;C00800;C00022;C00191;C00026;C01620 | 47 | 9.41E-05 | 0.00295 |
| Taurine and hypotaurine metabolism | KO00430 | C00022;C00025;C00026;C00094 | 22 | 0.000377 | 0.00731 |
The KEGG IDs for all 65 metabolites with a high pq2 score (>0.05, see Fig 2B) were used for the pathway enrichment analysis (http://impala.molgen.mpg.de/impala/impala). The Q-value cut-off were < 0.01.