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. Author manuscript; available in PMC: 2016 Mar 27.
Published in final edited form as: Expert Rev Clin Immunol. 2015 Apr 27;11(7):793–803. doi: 10.1586/1744666X.2015.1040394

Figure 1. Shared mediators of obesity and airway reactivity (AHR) regarding early and late onset.

Figure 1

Mouse models of early obesity (ob/ob and db/db mice) exhibit developmental differences and share characteristic mediators with early onset airways hyperresponsiveness (AHR). Conversely, chronic inflammation appears to play a role in both obesity that develops over time as well as later-onset airway hyperreactivity.