Table 1.

Findings in mouse models of obesity and metabolic abnormalities related to obesity.

Mouse model	Innate airway reactivity	Response to allergen challenge	Response to ozone
ob/ob, lack leptin	↑	↓ Inflammation ↑ AHR	↑ Inflammation & AHR (IL-6 dependent)
db/db, lack leptin receptor	↑	↓ Inflammation ↑ AHR	↑ Inflammation ↑ AHR
Adiponectin deficiency	↑	↑ Inflammation ↑ AHR	↑ Inflammation & AHR (IL-6 & -17A dependent)
CPEfat	↑	↑ Inflammation ↑ AHR	↑ Inflammation ↑ AHR
High fat diet	↑	↑↓ Inflammation† ↑ AHR	↑ Inflammation ↑ AHR

‘Inflammation’ in this context refers to increased airway inflammation documented most often by bronchoal-veolar lavage cell counts.

^†Both increased and decreased inflammation in response to aeroallergen have been reported in various strains, with different allergens.

AHR: Airway hyperreactivity.