TABLE 3.
SUMMARY OF SPECIMENS WITH POLYMORPHISMS AND OR DRUG RESISTANCE MUTATIONS AT BASELINE
| IDs | Subtype |
Scored resistance mutations
|
Resistance levela
|
||||
|---|---|---|---|---|---|---|---|
| PR | RT | Sensitiveb | Low | Intermediate | High | ||
| 5149 | A/CRF02-AG | None | V179I | ||||
| 5292 | A/CRF02-AG | None | V179I | ||||
| 5152 | A/CRF15-01B | None | V179I | ||||
| 5165 | A/CRF15-01B | None | V179I | ||||
| 5313 | A/CRF15-01B | None | V179IV | ||||
| 5123 | A/CRF15-01B | None | V179I | ||||
| 5305 | A/CRF15-01B | None | V90I | ||||
| 5168 | A/CRF36-cpx | None | T69N, V106I | ||||
| 5213 | A/CRF36-cpx | T74S | T69NT | All remaining PI | NFV | ||
| 5214 | A/CRF36-cpx | None | G190AG | ETR, RPV | EFV | NVP | |
| 5225 | A/CRF36-cpx | None | T69N, K101E, V108IV, G190A | ETR | RPV | EFV, NVP | |
| 5251 | A/CRF36-cpx | None | V179AT | ||||
| 5253 | A/CRF36-cpx | None | E138A | ||||
| 5312 | A/CRF36-cpx | I85V | T69NT | ||||
| 5330 | A/CRF36-cpx | None | E138A | ||||
| 5345 | A/CRF36-cpx | F53FY | V118I | ||||
| 5217 | C | T74S | None | All remaining PIs | NFV | ||
| 5074 | CRF02-AG | None | V90I | ||||
| 5093 | CRF02-AG | T74S | None | All remaining PIs | NFV | ||
| 5169 | CRF02-AG | None | T69ST | ||||
| 5188 | CRF02-AG | None | E138A | ||||
| 5228 | CRF02-AG | None | K103N | ETR, RPV | EFV, NVP | ||
| 5289 | CRF02-AG | None | V118I | ||||
| 5293 | CRF02-AG | None | T69ST | ||||
| 5304 | CRF02-AG | None | E138A | ||||
| 5306 | CRF02-AG | None | E138AE | ||||
| 5183 | CRF06-cpx | None | M41L, E44DE, V179E | 3TC, ABC, ddI, FTC, TDF | AZT, d4T | ||
| 5208 | CRF06-cpx | None | V90I | ||||
| 5241 | CRF06-cpx | None | V179E | ||||
| 5250 | CRF06-cpx | None | V179E | ||||
| 5279 | CRF06-cpx | None | V179E | ||||
| 5294 | CRF06-cpx | None | V179E | ||||
| 5328 | CRF06-cpx | None | V179E | ||||
| 5206 | CRF25-cpx | A71V | None | ||||
| 5248 | CRF25-cpx | None | V179I | ||||
| 5318 | CRF25-cpx | None | V179I | ||||
| 5100 | CRF36-cpx | None | V179I | ||||
| 5326 | CRF36-cpx | None | V118I | ||||
| 5089 | CRF36-cpx/B | None | V179I | ||||
| 5223 | CRF36-cpx/B | None | V179I | ||||
| 5079 | CRF43-02G | None | E138A | ||||
| 5084 | CRF43-02G | None | V179EV | ||||
| 5087 | CRF43-02G | T74S | None | All remaining PIs | NFV | ||
| 5106 | CRF43-02G | None | V179E | ||||
| 5174 | CRF43-02G | None | K101Q | ||||
| 5184 | CRF43-02G | None | V118I, E138A | ||||
| 5195 | CRF43-02G | None | V179E | ||||
| 5211 | CRF43-02G | T74S | T69A | All remaining PIs | NFV | ||
| 5238 | CRF43-02G | None | T69S | ||||
| 5315 | CRF43-02G | None | V118IV | ||||
| 5116 | G | None | V90I, V179IV | ||||
| 5119 | G | None | V118I | ||||
| 5142 | G | None | V106I | ||||
| 5161 | G | None | V179IMV | ||||
| 5194 | G | M46L | None | All remaining PIs | NFV | ||
| 5201 | G | None | E138A | ||||
| 5205 | G | None | A98G | EFV, ETR, RPV | NVP | ||
| 5220 | G | None | V75MV, K103R | ||||
| 5222 | G | None | V118IV | ||||
| 5226 | G | None | V179E | ||||
| 5233 | G | None | E138A | ||||
| 5237 | G | None | E138AE | ||||
| 5242 | G | None | V179E | ||||
| 5247 | G | None | V118I | ||||
| 5256 | G | None | V118I | ||||
| 5278 | G | None | K101Q, K103R | ||||
| 5296 | G | None | T69ST | ||||
| 5300 | G | None | V106IV, V118IV | ||||
| 5308 | G | None | V106I | ||||
| 5314 | G | None | M41L, V90I | 3TC, ABC, ddI, FTC, TDF | AZT, d4T | ||
| 5316 | G | T74S | None | All remaining PIs | NFV | ||
| 5336 | G | K43KT | None | ||||
| 5338 | G | None | V106I, V118IV | ||||
| 5320 | G | None | E138A | ||||
| 5325 | G | None | E138A | ||||
| 5299 | U | None | K101EK, E138A | DLV, ETR | EFV | NVP, RPV | |
a
Sensitivity column is filled only when drugs are resistant.
b
Potential low level of resistance is classified as sensitive as per WHO interpretation.
NFV, nelfinavir; EFV, efavirenz; NVP, nevirapine; ETR, etravirine; RPV, rilpivirine; AZT, zidovudine; d4T, stavudine; ABC, abacavir; 3TC, lamivudine; ddI, didanosine; FTC, emtricitabine; TDF, tenofovir.