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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Brain Res Bull. 2015 Nov 22;120:131–143. doi: 10.1016/j.brainresbull.2015.11.015

Figure 3. Flumazenil exposure reduces responses of recombinant α4Fβ2δ GABARs to gaboxadol.

Figure 3

Whole cell patch clamp recordings of peak current responses (in pA) to acutely applied gaboxadol (GBX, 100 nM) in cells treated for 48 h with GABA plus THP or vehicle as well as FLU for the indicated times. A, Summary data and B, representative current traces show that long-term FLU treatment (6, 24, 48 h) reduces GBX-gated current. Arrow, start of ~500 ms ligand application. (n=5 cells/group, *F(6,28)=36.7, P<0.0001, ANOVA; P<0.05 vs. 48 h GABA+THP with 48 h FLU, post-hoc Tukey’s test).