Table 3.

Peripheral nerve functioning and longitudinal performance in LDCW from 2000/01 to 2006/07 in the Health, Aging and Body Composition study

	Model 1		Model 2		Model 3: Final Model
	Standardized Betas		Standardized Betas		Standardized Betas
	Main Effect	Time Interaction	Main Effect	Time Interaction	Main Effect	Time Interaction
Motor Nerve Function
SD lower amplitude, mV	3.9*	0.5	3.7*	0.3	2.2	0.2
Poor amplitude	5.8	4.8**	3.2	4.4**	−0.8	4.7**†
SD Slower Conduction Velocity, m/sec	−0.8	−0.1	−0.5	0.3	1.1	0.3
Poor Conduction Velocity	−2.1	−0.04	0.9	−0.3	−3.9	−0.7
Sensory Nerve Function
SD higher vibration perception threshold, microns	5.2**	1.6**	4.9**	1.7**	3.4*	1.5**†
Poor vibration perception threshold	19.6**	4.1*	20.1**	4.9**	16.0*	4.2*
1.4 monofilament insensitivity	9.3**	−0.6	8.6**	−0.6	6.9*	−0.9
10-g monofilament insensitivity	20.7**	4.4**	16.3**	4.5**	14.4**	3.8**†

^*P<.05,

^**P≤.01.

^*P<.05,

^**P≤.01,

^†Significant using Bonferroni adjustment for 8 multiple comparisons, P<0.006).

Note: Model 1 is adjusted for age, sex, race and site; Model 2 Adjusted for Model 1 + health status, physical activity, current cigarette smoking, lean mass and fat mass; Model 3 Motor amplitude and conduction velocity: Model 2 + PAD, cerebrovascular disease, diabetes, insufficient renal function, shortness of breath while walking, and DSST score. Cigarette smoking and health status were removed. Model 3: Sensory nerves function: Model 2 + PAD, cerebrovascular disease, diabetes, insufficient renal function, DSST score, CES-D and hypertension. Cigarette smoking and health status were removed. Model 3: Vibration perception threshold: Model 2 + PAD, cerebrovascular disease, diabetes, insufficient renal function, DSST score, CES-D and hypertension, health status removed due to non-significance. Beta values for continuous predictors represent the decrease/increase in LDCW completion time based upon each standard deviation change representing worse nerve functioning. Continuous nerve function mean ± SD of those in the longitudinal sample (n=1178): Amplitude = 3.6 ± 2.0 mV, conduction velocity = 43.7 ± 5.4, and vibration threshold = 49.5 ± 34.6. Time interactions indicate the additional increase in LDCW completion time per year (change in slope) compared to the baseline category (for categorical variables) or for each standard deviation of worse nerve functioning.