Table 1.
The MIF -794 CATT5–8 promoter variants correlate with severity of WNV disease.
| E (%) n=73 |
All Other Disease (%) n=381 |
p-value, OR (CI) | M+ME (%) n=204 |
p-value, OR (CI) | |
|---|---|---|---|---|---|
| Alleles | |||||
| 5-CATT | 29 (19.86%) | 194 (25.46%) | 0.049 | 103 (25.25%) | 0.042 |
| 6-CATT | 91 (62.33%) | 483 (63.39%) | 263 (64.46%) | ||
| 7-CATT | 26 (17.81%) | 85 (11.5%) | 42 (10.29%) | ||
| Groups | |||||
| 7-CATT | 26 (17.81%) | 85 (11.15%) |
0.037, OR 1.73 CI (1.07–2.79) |
42 (10.29%) | 0.027, OR 1.89 (1.10–3.21) |
| All Others | 120 (82.19%) | 677 (88.85%) | 366 (89.71%) | ||
| Genotype | |||||
| 77-CATT | 4 (5.5%) | 7 (1.83%) | 0.0833 | 1 (0.5%) | 0.0174, 11.94 (1.32–108.70) |
| All other genotypes | 69 (94.5%) | 374 (98.2%) | 203 (99.5%) | ||
| Adjusted for Age/ Gender | |||||
| 0.0084, 21.54 (2.20, 210.90) |
In comparing the distribution of different CATT alleles among the different disease manifestations in the cases, the low-expresser 5-CATT allele was less common among encephalitis (E) cases, and the high-expresser 7-CATT allele was more common. This difference was significant comparing encephalitis (E) with all other neuroinvasive disease as well as with meningitis and meningoenceophaltitis alone (M + ME).