Table 1.
Characteristics of women by vasomotor symptom trajectory group
| Consistently Low | Early Onset | Late Onset | Consistently High | Overall P value |
|
|---|---|---|---|---|---|
| Age, years, Mean±SD | 59.8±2.6 | 59.7±2.6 | 59.2±2.6 | 59.5±2.8 | .06 |
| Race, n (%) | <.0001 | ||||
| Black | 30(13.2) | 43(32.1) | 67(29.8) | 98(43.8) | |
| Caucasian | 125(54.8) | 63(47.0) | 116(51.6) | 86(38.4) | |
| Chinese | 60(26.3) | 22(16.4) | 33(14.7) | 22(9.8) | |
| Hispanic | 13(5.7) | 6(4.5) | 9(4.0) | 18(8.0) | |
| Education, n (%) | <.0001 | ||||
| High school | 43(19.3) | 29(21.8) | 45(20.1) | 69(30.9) | |
| Some college/vocational | 51(22.9) | 39(29.3) | 67(29.9) | 86(38.6) | |
| ≥College | 129(57.9) | 65(48.9) | 112(50.0) | 68(30.5) | |
| BMI, kg/m2, Mean±SD | 28.3±7.3 | 30.5±7.4* | 28.0±6.2 | 31.3±7.7* | <.0001 |
| SBP, mmHg, Mean±SD | 117.9±15.5 | 124.5±18.5* | 119.0±15.7 | 125.2±19.0* | <.0001 |
| DBP, mmHg, Mean±SD | 73.0 ±9.8 | 75.6 ±11.1* | 72.8 ±10.1 | 74.5 ±9.7* | .03 |
| HDL, mg/dL, Mean±SD | 64.6±17.2 | 60.3±15.0* | 64.5±16.7 | 60.0±14.2* | .002 |
| LDL, mg/dL, Mean±SD | 123.9±34.6 | 126.4±29.5 | 128.7±36.6 | 123.3±35.6 | .40 |
| Triglycerides, mg/dL, Median (Q1,Q3) | 91.5(71.0, 125.5) | 101.0(76.0, 145.0)* | 87.0(69.0, 126.0) | 103.0(76.0, 140.0)* | .03 |
| HOMA index, Median (Q1,Q3) | 1.7(1.1, 3.4) | 2.6(1.5, 4.0)* | 1.7(1.1, 3.0) | 2.6(1.4, 4.2)* | <.0001 |
| Anxiety, Median (Q1,Q3) | 1.0(.0, 3.0) | 2.0(.0, 4.0) | 1.0(.0, 3.0) | 3.0(1.0, 6.0)* | <.0001 |
| Smoker, n (%) | 11 (4.9) | 9 (6.8) | 15 (6.7) | 30(13.6) | .004 |
| Diabetes, n(%) | 22(9.7) | 15(11.2) | 7(3.1) | 39(17.4) | <.0001 |
| Cardiovascular medication use, n (%)† | 103(45.4) | 75(56.4) | 103(46.4) | 144(64.6) | <.0001 |
*
Significant (p<0.05) difference compared to consistently low VMS;
†
Ever use during the study; Cardiovascular medications: antihypertensive, lipid lowering, or anticoagulants
BMI = body mass index; DBP = diastolic blood pressure; HDL = high density lipoprotein, HOMA = homeostatic model assessment, LDL = low density lipoprotein; Q = quartile; SBP = systolic blood pressure; SD = standard deviation