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. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: Mol Psychiatry. 2015 Jun 30;21(3):348–356. doi: 10.1038/mp.2015.85

Figure 2.

Figure 2

Amygdala and VS reactivity jointly moderated the relation between recent life stress and problem drinking. Slopes represent beta coefficient estimates reflecting the strength of the relation between LESS and AUDIT scores (a–b) or AUD diagnosis (c–d) at varying levels of amygdala and VS activity. High levels of stress were associated with larger increases in AUDIT scores for participants with a combination of (a) low VS (-1SD) and high amygdala (+1SD) reactivity or (b) high VS and low amygdala reactivity. High levels of stress were also associated with larger increases in the likelihood of having a concurrent AUD diagnosis for those with low VS and high amygdala reactivity (c), but not with those with high VS and low amygdala reactivity (d), for whom this relationship was only observed at 2.5 SD >mean (data not shown). Simple slopes are adjusted for gender, age, race/ethnicity and CTQ.