Fig. 2.

AN3CA endometrial tumor average response to treatment in a xenotransplant mouse model. Female BALB/c nu/nu mice were injected subcutaneously in the right flank with 2 × 10⁶ AN3CA cells, then mice randomized into treatment groups when tumors were 160 mm³. RAD001 (2.5 mg/kg) and PP242 (100 mg/kg) were administered by gavage on days 1–5 of each week, carboplatin (50 mg/kg, i.p.) was given on day 2 of the weekly cycle. Tumor sizes were determined by precision caliber twice weekly. Results represent the mean with SEM of two independent studies of 7–8 mice per treatment arm.