Table 3. Cox Regression Analysis of Variable Factors and HVPG for Mortality in Patients with Decompensated Cirrhosis.
| Parameters | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |
| Sex, male | 1.412 | 0.521-3.831 | 0.498 | |||
| Age, yr | 1.018 | 0.975-1.062 | 0.417 | |||
| Alcohol vs. non-alcohol | 1.408 | 0.518-3.827 | 0.503 | |||
| History of variceal bleeding | 2.033 | 0.878-4.711 | 0.098 | |||
| Presence of ascites | 1.999 | 0.676-5.911 | 0.210 | |||
| Use of beta-blocker | 1.042 | 0.425-2.558 | 0.928 | |||
| Platelet count, 103/µL (10 k increase) | 0.983 | 0.925-1.044 | 0.579 | |||
| Albumin, mg/dL (0.1 increase) | 0.892 | 0.822-0.969 | 0.007 | |||
| Bilirubin, mg/dL | 1.251 | 1.030-1.520 | 0.024 | 0.723 | 0.501-1.044 | 0.083 |
| Prothrombin time, INR (0.1 unit increase) | 1.195 | 1.078-1.326 | 0.001 | |||
| Creatinine, mg/dL (0.1 mg/dL increase) | 1.223 | 0.989-1.512 | 0.063 | |||
| Sodium, mEq/L | 0.892 | 0.815-0.975 | 0.012 | |||
| HVPG, mm Hg | 1.092 | 1.026-1.163 | 0.006 | 1.079 | 1.001-1.163 | 0.046 |
| MELD score | 1.175 | 1.075-1.285 | <0.001 | 1.279 | 1.099-1.488 | 0.001 |
HR, hazard ratio; CI, confidence interval; HVPG, hepatic venous pressure gradient; INR, international normalized ratio; MELD, model for end-stage liver disease.