Figure 3.
Increased footslips on narrow elevated beam at 7 months in SCA684Q/84Q mice. A–D, The number of mice that display footslips (0 footslips = lightest color, >2 footslips = darkest color, and 1 and 2 footslips graded in between) when crossing beams for the following three genotypes: WT (grayscale) SCA684Q/+ (orange scale), and SCA684Q/84Q mice (red scale); see legend on the right. No differences were seen across genotypes and age for the following: A, 22-mm-diameter beam (F(2,37) = 0.17; p = 0.85); B,18-mm-diameter beam (F(2,37) = 1.91; p = 0.16); C, 15-mm-diameter beam (F(2,37) = 0.65; p = 0.53); D, a significant increase in the number of footslips was observed for the 12-mm-diameter beam at 7 months for SCA684Q/84Q mice (F(2,37) = 4.19; p = 0.02). *p < 0.05; p > 0.05 where not indicated, one-way ANOVA followed by post hoc Tukey’s test; N = 8 − 10 SCA684Q/84Q mice depending on age, 5 − 9 SCA684Q/+ mice, and 6 − 9 WT mice (consult Table 1 for sample size at each age).