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. 2015 Dec 26;2(6):ENEURO.0094-15.2015. doi: 10.1523/ENEURO.0094-15.2015

Figure 6.

Figure 6.

Disease progression marked by no gait abnormalities, but worsening motor coordination. A–F, Gait was examined in aging animals that were 1 and 2 years old to determine whether differences in gait emerged as SCA6 progressed. The stride lengths at 1 and 2 years were not significantly different across SCA684Q/84Q and WT mice for the following: A, left hindlimb (F(1,27) = 0.08; p = 0.77); B, left forelimb (F(1,27) = 0.01; p = 0.90); C, right hindlimb (F(1,27) = 0.002; p = 0.97); and, D, right forelimb stride lengths (F(1,27) = 0.10; p = 0.76). Nor were significant differences observed for stance (distance between left and right limb placements) of the following: E, hindlimbs (F(1,27) = 0.0001; p = 0.99); and F, forelimbs (F(1,27) = 0.17; p = 0.68). G, Motor coordination abnormalities worsened with age for 1- and 2-year-old mice on rotarod (1 year: Genotype, F(1,30) = 56.01; p < 0.0001; 2 year: Genotype, F(1,28) = 33.62; p < 0.0001). ***p < 0.001 one-way ANOVA followed by Tukey’s post hoc test; N = 8 WT and 8 SCA684Q/84Q 1-year-old mice; n = 7 WT and 8 SCA684Q/84Q 2-year-old mice.