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. 2015 Dec 26;2(6):ENEURO.0096-15.2015. doi: 10.1523/ENEURO.0096-15.2015

Figure 5.

Figure 5.

Loss of vestibular efferent neurons in the Hoxb1-null mutant. A–B', In situ hybridization for Gata3 transcripts (A, A') and Hoxb1-driven expression of YFP (B, B') in wild-type (wt) and Hoxb1-null mouse embryos. Gata3 in situ hybridization in wild-type mice labels the vestibular efferent neurons (VEN) in the specific region of r4 where they differentiate (A, B, arrows). In Hoxb1-null mice, this region is devoid of Gata3 expression (A', *). The application of DiI to the peripheral nerves in the inner ear at P8 retrogradely labels vestibular efferent neurons in wild-type mice (C, VEN), but not in Hoxb1-null mice (C', *).