Table 4. Univariate and multivariate survival analysis of TNM IIIb/IIIc GC patients by Cox proportional hazards model.

Characteristics	n	3-year OS (%)	Univariate analysis			Multivariate analysis
			HR (95% CI)	P		HR (95% CI)	P
Sex
Male	267	37.1	1 (ref)
Female	106	32.1	1.015 (0.783-1.315)	0.911
Age at surgery (year)
<65	247	40.1	1 (ref)			1 (ref)
≥65	126	27.0	1.473 (1.157-1.876)	0.002		1.238 (0.962-1.593)	0.097
Tumor diameter (cm)
<5	114	44.7	1 (ref)			1 (ref)
≥5	259	31.7	1.413 (1.089-1.834)	0.009		1.262 (0.967-1.646)	0.086
Borrmann type
I	26	69.2	1 (ref)			1 (ref)
II	78	38.5	1.490 (0.840-2.641)	0.172		1.506 (0.843-2.690)	0.167
III	216	33.8	1.875 (1.105-3.181)	0.020		1.743 (1.016-2.990)	0.044
IV	53	22.6	2.770 (2.541-4.976)	0.001		2.346 (1.285-4.280)	0.005
Histology
Differentiated	74	47.3	1 (ref)			1 (ref)
Undifferentiated	299	32.8	1.430 (1.052-1.942)	0.022		1.305 (0.954-1.785)	0.095
Curability
R0	325	36.6	1 (ref)			1 (ref)
R1	48	29.2	1.511 (1.080-2.115)	0.016		1.208 (0.847-1.724)	0.297
TNM stage
IIIb	162	47.5	1 (ref)			1 (ref)
IIIc	211	26.6	1.742 (1.367-2.220)	<0.001		1.769 (1.385-2.261)	<0.001
Postoperative chemotherapy
Yes	230	42.2	1 (ref)			1 (ref)
No	143	25.2	1.485 (1.171-1.881)	0.001		1.488 (1.161-1.906)	0.022
Type of gastrectomy
Subtotal	217	37.3	1 (ref)
Total	156	33.3	1.168 (0.922-1.479)	0.197
Status of 14v dissection
14vD (+)	103	48.5	1 (ref)			1 (ref)
14vD (−)	270	30.7	1.500 (1.143-1.968)	0.003		1.568 (1.186-2.072)	0.002

GC, gastric cancer; OS, overall survival; HR, hazard ratio; CI, confidence interval; 14vD, 14v dissection.