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. 2015 Dec 28;7(12):438–447. doi: 10.4329/wjr.v7.i12.438

Figure 3.

Figure 3

Progressive multifocal leucoencephalopathy. HIV patient with + JC virus on PCR-CSF. Bilateral involvement of MCP on axial FLAIR (A); with no enhancement (not shown); Axial FLAIR (B) and axial DWI (C) images show asymmetric confluent areas of increased signal in the subcortical WM with involvement of the u-fibers (arrow) and linear “edge” on DWI (arrow on C) consistent with advancing demyelinated edge; D: Three months f/u images better depict involvement of u-fibers (white arrow) as well as progression of WM disease with formation of small central cavitation/micro cyst, characteristic of PML (black arrow). PML: Progressive multifocal leucoencephalopathy; MCP: Middle cerebellar peduncles; CSF: Cerebrospinal fluid; DWI: Diffusion weighted-imaging; PCR: Polymerase chain reaction; HIV: Human immunodeficiency virus.