Fig. 4.

Aurovist contrast agent extravasation.

Aurovist contrast extravasation (dark staining) was observed in (A) H&E stained sections of day 14 thrombi. Contrast extravasation occurred in highly organised regions of the thrombus rich in (B) Mac-2 positive macrophages and (C) CD31 positive neovascular channels (arrow heads) and (D) cellular iron deposits (scale bar 40 μm). The area of thrombus containing Aurovist correlated with (E) macrophage content (r = 0.41, P < 0.01), (F) neovascularisation (r = 0.60, P < 0.0001) and (G) iron deposits (r = 0.78, P < 0.0001), Spearman's rank n = 38 sections per group.