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(a) Schematic illustration of the stepwise aptasensor fabrication process and the dual signal amplification mechanism, adapted from [64]; (b) schematic diagram of fabrication and detection of the ECL aptasensor, adapted from [65]; and (c) results of molecular modeling related to (A) groove binding of small molecules to the minor groove of dsDNA and (B) groove binding of fullerene-C60 to the major groove of dsDNA, adapted from [66].
