FIGURE 2.

Increased pancreatic islet cellularity in serpin B13 mAb-treated mice. A and B, Balb/c male mice were injected with a low (4 × 2.5 μg) or high (4 × 25 μg) dose of serpin B13 mAb or IgG control, as described in the legend to Fig. 1B. The animals were sacrificed at 8 weeks old, and their pancreata were prepared for insulin staining and FACS. The average total cellularity (A) and beta cell number per islet (B) are shown. The islets from experiments depicted in Fig. 1C were used for the analysis. C and D, Balb/c male mice were injected with serpin B13 mAb or IgG control (4 × 25 μg), as described in the legend to Fig. 1, B (2-month follow up), and E (9-month follow up), respectively. The data depicted in C and D are based on mice that were also used for the analysis depicted in Fig. 1, D and F, respectively. Data are presented as mean ± S.E.