FIGURE 3.

Linear regression analysis of beta cellularity according to islet section size in IgG- and serpin B13 mAb-treated mice. Pancreatic tissue blocks were obtained from the same Balb/c male mice that were used in the experiments depicted in Fig. 1. Tissue sections were stained with an anti-insulin Ab and DAPI, and nuclei in small and larger beta cell cluster sections were quantified. A, analysis of small islet sections. A total of 20,429 nuclei in the IgG-treated group and 23,497 nuclei in the serpin B13 mAb-treated group were examined to generate the formulae. B, analysis of larger islet sections. A total of 36,598 nuclei in the IgG-treated group and 41,589 nuclei in the serpin B13 mAb-treated group were examined to generate the formulae.