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. 2015 Nov 6;291(1):334–341. doi: 10.1074/jbc.M115.685289

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FIGURE 4. — Cooperative interaction between STIM1 fragments and the N and C termini of Orai1 controls regulation of ion selectivity. A, average of normalized plots of the current-voltage relationship recorded in 10 mm Ca²⁺ Ringer's solution from cells expressing the indicated double or triple Orai1-SS mutants. Arrows indicate the reversal potential in each instance. B, summary of reversal potentials and current densities recorded from cells expressing the indicated Orai1-SS mutants (n = 5–6 cells). Dashed red columns show the predicted additive effect for the double mutants. *, p < 0.05; **, p < 0.01. pF, picofarad.