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. 2015 Nov 17;291(1):413–424. doi: 10.1074/jbc.M115.686709

FIGURE 1.

FIGURE 1.

Hypoxia potentiates palmitate-induced, pro-inflammatory cytokine expression and secretion in primary human macrophages. A–E, mRNA expression of TNF-α (A), IL-6 (B), IL-1β (C), IL-8 (D), and IL-10 (E) in primary human macrophages treated with 500 μm palmitate (C16:0) or BSA alone for 9 h under normoxia (20% O2) or hypoxia (1% O2). F–J, protein concentrations of TNF-α (F), IL-6 (G), IL-1β (H), IL-8 (I), and IL-10 (J) in cell culture supernatants after 24-h treatment with C16:0 or BSA alone under normoxia or hypoxia. K–O, mRNA expression of Tnfa (K), Il6 (L), Il1b (M), Nos2 (N), and Il10 (O) in murine SVFs treated with 500 μm C16:0 or BSA alone for 9 h under normoxia (20% O2) or hypoxia (1% O2). Results are presented as mean ± S.E. of at least four independent experiments. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ns, not significant.