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. 2015 Nov 12;291(1):89–102. doi: 10.1074/jbc.M115.680918

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© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — Synthetic Fab 3G11 inhibits BAX-mediated cytochrome c release and BAX mitochondrial translocation induced by pro-apoptotic tBID in isolated mitochondria. A, Fab 3G11 inhibits, dose-responsively, tBID-induced BAX-mediated cytochrome c release from isolated BAK^−/− mitochondria. WB, Western blot. B, 3G11 Fab inhibits, dose-responsively, tBID-induced BAX mitochondrial translocation in isolated BAK^−/− mitochondria. The data shown are representative of at least three independent experiments.