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. Author manuscript; available in PMC: 2015 Dec 31.
Published in final edited form as: Expert Opin Ther Targets. 2014 Sep 18;19(1):37–54. doi: 10.1517/14728222.2014.960843

Figure 1. The FLT3 receptor.

Figure 1

FLT3 ligand (FL) binds in dimeric form to induce receptor dimerization. FLT3/ITD mutations are inserted into the juxtamembrane domain.

C: C-lobe of kinase domain; FLT3: FMS-like tyrosine kinase-3; ITD: Internal tandem duplications; N: N-lobe of kinase domain.