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. Author manuscript; available in PMC: 2015 Dec 31.
Published in final edited form as: Curr Med Chem. 2015;22(35):4091–4103. doi: 10.2174/0929867322666150827094015

Fig. (3). Pre-clinical cancer therapeutic studies of Porcn and Tnks inhibitors in mice.

Fig. (3)

C59 and JW55 are predecessor molecules of LGK-974 and G007-LK, respectively. MMTV-Wnt1 transgenic mice develop ductal hyperplasia in mammary gland tissue due to introduction of a viral transcriptional enhancer that induces Wnt1 expression. Liu et al has shown that loss of Notch signaling in head and neck squamous cell carcinoma cell lines induce cell growth-promoting Wnt/β-catenin signaling. Thioacetamide is a chemical that induces dysregulated growth in the biliary tract of animals that are compromised for the p53 tumor suppressor. Juan et al. has shown that lung cancers initiated by a mutation in the protooncogenic Braf protein (V600E) are dependent upon β-catenin signaling.