Table 2. Receiver operating characteristics curve analysis results for each biomarker in the discrimination of septic patients from non-septic patients*.
| Tests | AUC (95% CI) | Best cutoff | Sensitivity (95% CI) | Specificity (95% CI) | NPV | PPV | Accuracy (95% CI) |
|---|---|---|---|---|---|---|---|
| LA | 0.781 (0.714-0.840) | > 2.0 mmol/L | 50.5% (35.4-54.3%) | 92.3% (75.7-97.9%) | 80.8% | 98.1% | 55.2% (45.7-62.6%) |
| PCT | 0.923 (0.873-0.957) | > 1.38 ng/mL | 71.1% (56.8-74.3%) | 100.0% (87.1-100.0%) | 68.7% | 100.0% | 74.4% (64.5-79.4%) |
| CRP | 0.940 (0.894-0.970) | > 5.25 mg/dL | 77.5% (74.3-88.5%) | 97.9% (88.9-99.6%) | 50.5% | 99.4% | 81.3% (81.0-91.5%) |
| IPF | 0.868 (0.810-0.914) | > 3.1% | 89.8% (84.9-99.8%) | 53.2% (39.2-66.7%) | 46.8% | 89.8% | 83.2% (78.8-90.0%) |
| IG | 0.812 (0.747-0.867) | > 0.4% | 67.0% (56.8-74.3%) | 74.5% (60.5-84.7%) | 67.0% | 92.3% | 68.3% (60.9-75.3%) |
| IRF | 0.658 (0.584-0.727) | > 5.6% | 77.6% (71.8-87.9%) | 56.0% (37.1-73.3%) | 75.9% | 93.3% | 75.1% (67.1-82.6%) |
*The sensitivity, specificity, negative predictive value, positive predictive value, and accuracy of each biomarker were calculated from the application of predefined best cutoff values for each biomarker.
Abbreviations: LA, lactate; PCT, procalcitonin; CRP, C-reactive protein; IPF, immature platelet fraction; IG, immature granulocyte fraction; IRF, immature reticulocyte fraction; AUC, area under the curve; CI, confidence interval; NPV, negative predictive value; PPV, positive predictive value.