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Tmem178 deficiency enhances osteoclastogenesis. (A) Q-RT PCR analyses of Tmem178 mRNA during RANKL-induced osteoclastogenesis in WT and PLCγ2−/− cells. (B) Q-RT PCR analysis of Tmem178 mRNA in human OC cultures. **P < 0.01. (C) TRAP staining of WT and Tmem178−/− OCs. Images are representative of more than five experiments, each performed in triplicate. (D) Quantification of TRAP+ OCs in D. *P < 0.05, ***P < 0.001.
