(A) Western blot analysis of RANKL-induced JNK, ERK, p38, and NF-κB in WT and Tmem178−/− BMMs (Top) and day 2 preOCs (Bottom), representative of three experiments. (B) Western blot analysis of M-CSF-induced AKT and ERK activation in WT and Tmem178−/− BMMs (Top) and day 2 preOCs (Bottom), representative of three experiments.