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. 2015 Dec 13;7(3):136–144.

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IJPPP Copyright © 2015

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Repeated chronic ethanol drinking induces pain hypersensitivity. The paw withdrawal threshold to mechanical (A) and paw withdrawal latency to heat stimuli (B) in SD rats at 4, 8 and 12 weeks in the IA2BC program. The paw withdrawal threshold and paw withdrawal latency in rats that in IA2BC program for 8 and 12 weeks was significantly lower than that of ethanol-naïve counterparts. Data are presented as mean ± SEM. (*)P < 0.001 compared to naïve rats. (#)P < 0.001, compared to baseline (BL) or 4 weeks after ethanol exposure, n = 25 rats for each group.