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The mechanical and thermal pain thresholds further decreased during withdrawal in SD rats that were in IA2BC for 12 weeks. The paw withdrawal threshold (A) and paw withdrawal latency (B) significantly decreased starting at 12 hours after ethanol removal and lasted for 7 days. Data is presented as mean ± SEM. (*)P < 0.001 compared to naïve rats. (#)P < 0.001, compared to 0 h after ethanol removal, n = 25 rats for each group.
