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. 2015 Oct 15;5(11):3325–3338.

Figure 5.

Figure 5

Inhibition of melanoma cell migration by GSPs is β-catenin dependent. A. Treatment of Mel1241 cells (β-catenin-activated) with GSPs inhibits cell migration capacity in a dose-dependent manner, while GSPs were failed to inhibit the migration of Mel1011 cells, which are β-catenin-inactivated. B. Migratory cells were counted on the membrane under microscope and results are expressed as the mean number of migratory cells ± SD per microscopic field (n = 3). C. Treatment of Mel1241 cells with CCT036477, a β-catenin inhibitor, inhibits cell migration capacity in a dose-dependent manner, while CCT036477 was failed to significantly inhibit the migration of Mel1011 cells. Representative photomicrographs are shown. D. Migratory cells were counted on the membrane under microscope and results are expressed as the mean number of migratory cells ± SD per microscopic field (n = 3). Significant inhibition in Mel1241 cells versus non-GSPs-treated or non-CCT036477-treated control cells, ¶P<0.05; *P<0.001.