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MLN4924 activated caspases, PARP, phospho-Histone H2A.X, and Bid and decreased Bcl-2 phosphorylation in human CC cells. Total cell lysates were harvested and analyzed by Western blotting with specific antibodies against (A) apoptosis-related molecules (PARP, cleaved caspase-3, -7 and -8), DNA damage response regulator (phospho-Histone H2A.X), (B) Bid, and phospho-Bcl-2 (Ser70). Results shown represent at least three independent experiments.
