Figure 5.

MLN4924 significantly abolished the growth of CC xenografts in vivo. Nu/Nu nude mice bearing ME-180 and HeLa CC tumor xenografts were injected intraperitoneally with DMSO (as the non-treated control; ME-180: n = 7, HeLa: n = 8) or MLN4924 (10 mg/kg; ME-180: n = 8, HeLa: n = 7) once per day for 32 days. A. The tumor images represent excised tumors from each group. B. The tumor weights were compared between the MLN4924-treated and control (DMSO) groups on the last day of treatment. Tumor weights are presented as the mean ± S.D.; *P < 0.05. C. The tumor volumes measured during the treatment are presented as the responses. Tumor volumes are presented as the mean ± SEM; *P < 0.05.