Survival analysis according to the VEGF/sVEGFR2 ratio. Kaplan-Meier curves for overall survival of two groups divided by the VEGF/sVEGFR2 ratio higher or lower than its median value (A). Forest plot of hazard ratios (HR) and 95% confidence intervals (CI) for overall survival assessed by subgroup factors (B). Abbreviation: ECOG, Eastern Cooperative. Group performance status; HER2, human epidermal growth factor receptor 2; mOS, median overall survival; VEGF, vascular endothelial growth factor; sVEGFR2, soluble vascular endothelial growth factor receptor 2; n/a, not applicable.