Table 2.

Distribution frequency of EZH2 genotypes in 552 controls and 576 oral cancer patients

Variable	Controls (N=552) n (%)	Patients (N=576) n (%)	OR (95% CI)	AOR (95% CI)
rs6950683
TT	264 (47.8%)	308 (53.5%)	1.00	1.00
TC	220 (39.9%)	221 (38.4%)	0.861 (0.671-1.104)	0.893 (0.622-1.280)
CC	68 (12.3%)	47 (8.2%)	0.592 (0.395-0.890)*	0.492 (0.274-0.884)*
TC+CC	288 (52.2%)	268 (46.5%)	0.798 (0.631-1.008)	0.790 (0.563-1.108)
rs2302427
CC	346 (62.7%)	356 (61.8%)	1.00	1.00
CG	171 (31.0%)	200 (34.7%)	1.137 (0.883-1.463)	0.930 (0.646-1.405)
GG	35 (6.3%)	20 (3.5%)	0.555 (0.314-1.002)	0.611 (0.265-1.405)
CG+GG	206 (37.3%)	220 (38.2%)	1.038 (0.816-1.321)	0.883 (0.623-1.250)
rs3757441
TT	271 (49.1%)	312 (54.2%)	1.00	1.00
TC	223 (40.4%)	221 (38.4%)	0.861 (0.672-1.102)	0.887 (0.620-1.269)
CC	58 (10.5%)	43 (7.5%)	0.644 (0.420-0.987)*	0.524 (0.284-0.968)*
TC+CC	281 (50.9%)	264 (45.8%)	0.816 (0.646-1.031)	0.804 (0.573-1.127)
rs41277434
AA	517 (93.6%)	540 (93.7%)	1.00	1.00
AC	34 (6.2%)	35 (6.1%)	0.986 (0.606-1.604)	1.546 (0.784-3.048)
CC	1 (0.2%)	1 (0.2%)	0.957 (0.060-15.347)	3.341 (0.157-70.898)
AC+CC	35 (6.4%)	36 (6.3%)	0.985 (0.609-1.592)	1.590 (0.814-3.104)

The odds ratios (ORs) and with their 95% confidence intervals (CIs) were estimated by logistic regression models. The adjusted odds ratios (AORs) with their 95% confidence intervals (CIs) were estimated by multiple logistic regression models after controlling for age, gender, betel nut chewing, tobacco and alcohol consumption.