Figure 9.

PF-3644022 (MK2 inhibitor) reduced the Bax/Bcl-2 ratio in twy/twy mice. The expressions of Bax (21 kDa) and Bcl-2 (26 kDa) in the spinal cord undergoing chronic compression were detected by Western blot assay. A. Western blot assay of Bax and Bcl-2 expressions. B. Quantification of Bax and Bcl-2 expressions and determination of Bax/Bcl-2 ratio (n=4 for control and twy/twy groups; n=3 for MK2 inhibitor group). Data are expressed as mean ± SEM. ###P<0.001 vs ICR mice; **P<0.01 vs twy/twy mice.