Extended Data Figure 4. Potential targets of Tet2 during immune response.

a–d, ELISA of cytokines in supernatants of splenic activated CD4⁺ T cells (a), CD8⁺ T cells (b) and NK cells (c), and conventional splenic CD19⁺ B cells (d) from Tet2-deficient (KO) and control mice (WT). T cells were stimulated with 10 μg ml⁻¹ anti-CD3 and 1 μg ml⁻¹ anti-CD28 monoclonal antibodies for 24 h. NK cells were stimulated with a combination of 10 ng ml⁻¹ IL-12 plus 5 ng ml⁻¹ IL-18 for 12 h. B cells were stimulated with 5 μg ml⁻¹ LPS for 24 h, Error bars represent s.d. of triplicate technical replicates and are representative of three independent experiments. **P < 0.01.