Fig 2. Positive selection in East Asians for genes regulated by vitamin D in bone.

The y axis shows the −log₁₀ of the combined p-value summarized from individual frequency-spectrum-based analysis on sets of Vitamin D (A) and Folate (B) related genes in three continental populations. The dashed horizontal line depicts the threshold of the −log₁₀ p-value for multiple comparisons after applying the Bonferroni correction (13 populations x 9 gene sets). (C). Positive selection in East Asians for genes regulated by vitamin D in bone. African (AFR) populations included ASW (African Ancestry in Southwest USA), LWK (Luhya in Webuye, Kenya) and YRI (Yoruba in Ibadan, Nigeria). Asians (ASN) were represented by CHB (Han Chinese in Beijing, China), CHS (Han Chinese South China) and JPT (Japanese in Tokyo, Japan); Europeans (EUR) included CEU (Utah residents with ancestry from northern and western Europe), FIN (Finnish in Finland), GBR (British from England and Scotland, UK) and TSI (Tuscans in Italy). Americans (AMR) were CLM (Colombians from Medellin, Colombia), MXL (Mexican Ancestry in Los Angeles, California, USA) and PUR (Puerto Rican in Puerto Rico, USA).