Table 3. Multivariate model for transplantation-free and overall survival.

Covariates	Model without aberrant methylation score				Model with aberrant methylation score
	Transplantation-free survival		Overall survival		Transplantation-free survival		Overall survival
	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value
Mutation in PTPN11 or NF1	2.5 (1.2–5.1)	0.01	2.1 (0.6–7.1)	0.24	3.5 (1.6–7.5)	0.002	2.1 (0.6–7.7)	0.24
Chromosomal aberration	3.7 (1.–7.1)	<0.001	3.8 (1.5–9.8)	0.006	2.3 (1.1–4.7)	0.021	4.1 (1.6–11)	0.004
Age at diagnosis >48 months	1.0 (0.5–1.8)	0.94	2.2 (0.9–5.2)	0.09	0.7 (0.4–1.4)	0.35	1.8 (0.7–4.5)	0.2
HbF >15%	1.7 (0.8–3.7)	0.15	1.9 (0.5–7.4)	0.33	1.0 (0.4–2.2)	0.92	1.2 (0.3–5.2)	0.79
PLT <33 × 109/L	2.0 (1.1–3.5)	0.02	2.8 (1.2–6.2)	0.015	1.6 (0.9–3.0)	0.1	3.1 (1.4–7.3)	0.007
Aberrant methylation score ≥1	–	–	–	–	4.1 (1.5–11)	0.006	4.4 (1.7–11)	0.002

Abbreviations: CI, confidence interval; HbF, hemoglobin F; HR, hazard ratio; PLT, platelets.