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. 2015 Dec 31;10(12):e0145467. doi: 10.1371/journal.pone.0145467

Fig 2. GW3965 treatment did not produce detectable reduction in amyloid beta load.

Fig 2

Amyloid plaque deposition in brains of treated and untreated mice groups were evaluated by immunohistochemistry and soluble Aβ (1–42) by ELISA. (A-B) Representative micrographs of brain sections of Aβ immunohistochemistry with antibody anti-Aβ (6E10). (C-D) No significant differences were observed on the anti-Aβ positive area in the hippocampus or cortex of treated 3xTg-AD mice. Data were expressed as mean ± S.E.M. Statistical analysis was done by one way ANOVA followed by Tukey's multiple comparison test. Females n = 4 per 3xTg-AD group. (E-F) RIPA soluble Aβ42 and Aβ40 in the hippocampus or cortex were measured by ELISA. Quantification data were expressed as mean ± S.E.M. Statistical analysis was done by one way ANOVA followed by Tukey's multiple comparison test. n = 5 per group.