Fig 2. NK cell cytotoxic control of MCMV requires both IL-12 and IFN-I signaling.

(A) Splenic viral titers and (B-F) escape (Δm157) frequency determined five days after a mixed MCMV infection (20000 PFU/mouse), as in Fig 1. (D) Anti-IFNAR1 antibody (or isotype control) was administered where indicated 24hrs prior to infection. Data are combined from two to three independent experiments with individual points representing a single mouse. L = Limit of quantification. I = Input frequency (10%).