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Growth inhibitory activities (IC50) of PTL, C1-C10-modified PTL analogues, and related probes to murine AML cell lines B117P, B117H, B140P, and B140H. IC50 values are mean ± S.D. in µM (n • 3 analyses).
| Compound | B117P | B117H | B140P | B140H |
|---|---|---|---|---|
| PTL | 1.1 ± 0.2 | 4.7 ± 1.6 | 5.8 ± 2.3 | 3.4 ± 1.1 |
| 1 | 6.4 ± 1.0 | 8.8 ± 1.7 | 10.0 ± 0.4 | 9.3 ± 1.5 |
| MelB | 2.1 ± 0.8 | 2.5 ± 1.0 | 2.9 ± 1.0 | 2.2 ± 0.7 |
| 4 | 2.9 ± 0.6 | 6.4 ± 2.1 | 13.5 ± 2.3 | 5.9 ± 2.4 |
| CTL | 3.5 ± 0.4 | 4.8 ± 0.7 | 3.6 ± 1.2 | 2.8 ± 0.7 |
