Table 3. Physical, plasma, and urine parameters.
Baseline | ||||||
Parameter | Sham | IR | IR+rIPerC | IR+rIPC | ||
BW, g | 258 ± 2.9 | 262 ± 2.9 | 268 ± 3.1 | 261 ± 2.2 | ||
Intakewater, mL | 46 ± 4.8 | 40 ± 2.6 | 44 ± 4.2 | 54 ± 2.8 | ||
Intakefood, g | 34 ± 8.9 | 19 ± 1.4 | 28 ± 8.9 | 19 ± 0.9 | ||
CrCl, mL/min/kg | 2.8 ± 0.4 | 3.1 ± 0.4* | 3.2 ± 0.3* | 2.4 ± 0.3* | ||
Pcr, μmol/L | 48 ± 5.4 | 56 ± 7.0 | 48 ± 2.8 | 56 ± 5.6 | ||
Purea, mmol/L | 10 ± 0.8 | 11 ± 1.2* | 12 ± 0.7* | 12 ± 0.7* | ||
Day 3 | ||||||
Parameter | Sham | IR | IR+rIPerC | IR+rIPC | ||
BW, g | 260 ± 5.1 | 249 ± 4.3 | 249 ± 3.7 | 241 ± 2.3* | ||
Intakewater, mL | 35 ± 4.0 | 34 ± 3.3 | 32 ± 3.4 | 35 ± 2.5 | ||
Intakefood, g | 15 ± 0.7 | 9 ± 1.0* | 8 ± 1.3* | 7 ± 0.5* | ||
CrCl, mL/min/kg | 5.2 ± 0.4 | 1.7 ± 0.4* | 1.7 ± 0.3* | 1.2 ± 0.3* | ||
Pcr, μmol/L | 34 ± 1.8 | 156 ± 46.4* | 142 ± 33.7* | 195 ± 32.3* | ||
Purea, mmol/L | 9 ± 0.2 | 28 ± 6.3* | 26 ± 5.3* | 34 ± 5.1* | ||
Day 7 | ||||||
Parameter | Sham | IR | IR+rIPerC | IR+rIPC | ||
BW, g | 251 ± 4.2 | 241 ± 5.1 | 245 ± 4.0 | 234 ± 1.9 | ||
Intakewater, mL | 27 ± 3.0 | 41 ± 3.3* | 40 ± 3.2 | 42 ± 3.6* | ||
Intakefood, g | 18 ± 0.7 | 16 ± 1.2 | 17 ± 1.0 | 15 ± 0.8 | ||
KW, g/100 g BW | 5 ± 0.2 | 11 ± 1.0* | 11 ± 1.1* | 12 ± 0.7* | ||
CrCl, mL/min/kg | 6.0 ± 0.6 | 3.5 ± 0.4* | 3.6 ± 0.3* | 2.8 ± 0.2* | ||
Pcr, μmol/L | 25 ± 2.0 | 55 ± 11.3* | 43 ± 2.7 | 61 ± 5.4* | ||
Purea, mmol/L | 6 ± 0.4 | 15 ± 3.6* | 12 ± 0.9* | 16 ± 1.8* |
Values are presented as means ± SEM. Group means were compared using either one-way analysis of variance followed by Bonferroni’s multiple comparison post-test or Kruskal-Wallis test with Dunn's multiple comparisons post-test.
*P < 0.05 vs. sham.
BW, body weight; Intakewater, 24-hour water intake; Intakefood, 24-hour food intake; KW, kidney weight; CrCl, creatinine clearance; Pcr, plasma creatinine; Purea, plasma urea; Uoutput, urinary output; FENa, fractional excretion of sodium; IR, ischemia-reperfusion; rIPerC, remote ischemic perconditioning; rIPC, remote ischemic preconditioning.