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. Author manuscript; available in PMC: 2016 Jun 3.
Published in final edited form as: Nature. 2015 Dec 3;528(7580):142–146. doi: 10.1038/nature15740

Figure 3. Single-cell Pico-Seq DHS data can predict cell-specific enhancers.

Figure 3

a. Genes with DHS in fewer single cells (x-axis) exhibit much higher variation of gene expression across different single cells (y-axis).

b. Genes with DHS in fewer single cells (y-axis) are expressed in fewer single cells (x-axis).

c. The NIH3T3-specific and ESC-specific DHSs identified in single cells showed expected cell specificity in all libraries.

d. The subpeaks of NIH3T3-specific super-enhancers showing much higher tag density in NIH3T3 cells than that in ES cells.

e. The subpeaks of ESC-specific super-enhancers showing much higher tag density in ES cells than that in NIH3T3 cells.