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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Lancet. 2014 Jan 8;383(9912):166–175. doi: 10.1016/S0140-6736(13)62227-8

Figure. Trends in three methodological quality indicators for reports of in-vivo studies.

Figure

We randomly sampled 2000 records from PubMed (published 1960–2012) on the basis of their PubMed ID (see appendix for details and the study dataset). 254 reports described in-vivo, ex-vivo, or in-vitro experiments involving non-human animals. Two investigators independently judged whether blinded assessment of outcome, randomisation, or a conflicts of interest statement were included. The proportion reports including this information is described in quintiles of publication year, along with their 95% CI. Sample size calculation, concealment of allocation sequence, or blinded conduct of the experiment were not reported for any study, so are not shown. The appendix contains detailed protocol, data extraction process, flow diagram, and raw data.