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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Aquat Toxicol. 2015 Dec 2;170:187–198. doi: 10.1016/j.aquatox.2015.11.004

Table 2.

Results of the mixed effects linear model for each of the explanatory factors at 10 dpf. The first column lists the explanatory factors and the subsequent columns represent separate effects models compared to the control. Values include coefficient ± SE (top) and p-value (bottom) for each row coinciding to the pre-defined categories used for morphological assessment compared to controls. Grey line separates the exposure groups (above) from the temporal factors (below).Bolded values are p≤0.05

Explanatory
Factors		 Mortality Hatching Total
Altered
Phenotypes		 Craniofacial
Abnormality		 Ocular
Deformities		 Pc/Ab
Edema		 Pericardial
Edema		 Notochord
Malformation		 Spleen
Color		 Gall
Bladder
Color		 Blood Pooling Swim Bladder Noninflation Other
Altered
Phenotypes
Female +
Male
Exposure		 4.06 ± 0.98 −1.33 ± 1.40 13.52 ± 1.71 2.47 ± 0.41 1.97 ± 0.24 1.22 ± 0.21 1.14 ± 0.20 0.29 ± 0.08 0.28 ± 0.09 0.33 ± 0.07 1.1 ± 0.24 27.18 ± 7.10 3.844 ± 0.41
< 0.001 0.343 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 0.003 < 0.001 < 0.001 < 0.001 < 0.001
Female
Only
Exposure		 5.65 ± 0.99 −3.09 ± 1.41 11.40 ± 1.72 1.09 ± 0.41 0.52 ± 0.25 1.81 ± 0.21 1.56 ± 0.20 −0.06 ± 0.08 0.35 ± 0.09 0.09 ± 0.07 1.0 ± 0.24 15.92 ± 7.19 4.16 ± 0.41
< 0.001 0.028 < 0.001 0.008 0.033 < 0.001 < 0.001 0.442 < 0.001 0.175 < 0.001 0.027 < 0.001
Male Only
Exposure		 5.71 ± 0.98 −3.10 ± 1.40 5.36 ± 1.72 0.40 ± 0.41 0.28 ± 0.24 0.96 ± 0.21 0.81 ± 0.20 −0.05 ± 0.08 0.30 ± 0.09 0.12 ± 0.7 0.26 ± 0.24 7.33 ± 7.31 1.85 ± 0.41
< 0.001 0.027 0.002 0.33 0.261 < 0.001 < 0.001 0.521 0.001 0.077 0.276 0.316 < 0.001
Embryo
Collection
Date		 1.82 ± 1.32 −0.48 ± 0.62 −0.84 ± 0.89 0.01 ± 0.16 0.004 ± 0.11 −0.07 ± 0.10 −0.05 ± 0.11 −0.03 ± 0.05 −0.08 ± 0.07 −0.07 ± 0.04 −0.21 ± 0.16 2.97 ± 2.77 −0.69 ± 0.23
0.168 0.441 0.347 0.956 0.971 0.482 0.62 0.621 0.206 0.077 0.197 0.283 0.003
Embryo dpf 1.65 ± 0.09 4.98 ± 0.13 1.89 ± 0.16 0.19 ± 0.04 0.14 ± 0.02 0.17 ± 0.02 0.13 ± 0.02 −0.01 ± 0.01 0.07 ± 0.01 0.04 ± 0.01 0.12 ± 0.02 3.02 ± 1.81 0.15 ± 0.04
< 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 0.119 < 0.001 < 0.001 < 0.001 0.095 < 0.001