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(a) Fluorescence photographs of B16F10 cells after the treatment with free siRNA or siRNA formulated in the GC4-targeted nanoparticles for 1 h. Fluorescence signal of FITC-labeled siRNA in B16F10 cells was observed by the confocal microscopy [101]. (b) Silencing effect of RRMI siRNA in A549 cells by neutral membrane/core nanoparticles (cRGD-CPE liposomes) with Lipofectamine 2000 as positive control. Adapted from ref [30].
