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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Trends Microbiol. 2015 Oct 29;24(1):26–34. doi: 10.1016/j.tim.2015.10.001

Figure 2. The PafE-proteasome System of M. tuberculosis.

Figure 2

PafE (blue) forms dodecameric rings and caps 20S CPs. This allows the ATP-independent opening of 20S CPs to facilitate the degradation of peptides and denatured proteins as well as HspR. HspR represses expression of the dnaK operon, clpB and hsp (Rv0249c). See text for details.