Table 4.

Pathway analysis. The integrated knowledge-based platform GeneGo was used to perform pathway analysis of differentially expressed protein coding genes in LOAD. The most enriched process networks are listed here

Networks	p Value	Min FDR	Network Objects from Active Data
Signal transduction_Neuropeptide signaling pathways	8.916E-04	5.573E-02	EDNRA (Galpha(q)-specific peptide GPCRs), GRP (GRP precursor), MCHR2, PRKAR1B (PKA-reg (cAMP-dependent)), PKD1L2, TAC1 (Substance P)
Neurophysiological process_Transmission of nerve impulse	1.230E-03	5.573E-02	SLC5A7 (CHT1), ADRB3 (Galpha(i)-specific amine GPCRs, Galpha(s)-specific amine GPCRs), HTR3B, SCN11A (NAV1.9), PRKAR1B (PKA-reg (cAMP-dependent)), TH (TY3H)
Muscle contraction	1.691E-03	5.573E-02	EDNRA (Galpha(q)-specific peptide GPCRs), ADRA1D (Galpha(q)-specific amine GPCRs), GUCA1C (GCAP), MYBPC1 (MYPS), CHRNA3 (nAChR alpha), TNNT2 (Troponin T, cardiac)
Development_Blood vessel morphogenesis	1.956E-03	5.573E-02	ADRB3 (Beta-3 adrenergic receptor, Galpha(i)-specific amine GPCRs, Galpha(s)-specific amine GPCRs), BMP4, EDNRA (EDNRA, EDNRB, Galpha(q)-specific peptide GPCRs), FGF10