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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Psychoneuroendocrinology. 2015 Nov 23;64:66–78. doi: 10.1016/j.psyneuen.2015.11.011

Figure 1.

Figure 1

Blocking CRFR 2 in the NAc shell (gray area in schematic drawing) eliminated heightened passive stress-coping after female partner loss.

A three-day separation from the female partner after five days of group housing resulted in increased floating in the forced swim test, indicative of passive stress-coping, in male prairie voles chronically infused with vehicle bilaterally into the NAc shell. Blocking CRFR2 with astressin-2B in the NAc shell diminished this increased passive stress-coping after separation. Activating CRFR2 by stresscopin increased passive stress-coping in the non-separated males. Passive stress-coping of male prairie voles treated with stresscopin or astressin-2B outside the NAc shell (“miss”; infusion site is depicted by the tips of black arrows in schematic drawing (Paxinos and Watson, 1998)) did not differ from vehicle-treated controls.

CP = caudate putamen; LV = lateral ventricle. Numbers of animals included in the statistics were vehicle paired = 6; separated = 5; antagonist paired = 7; separated = 10; agonist paired = 9; separated = 7; miss = 1. Data are expressed as mean + sem. ** p = 0.001 vs corresponding vehicle-treated group; ## p = 0.001 vs corresponding female-paired group.